Metformin: Anti Aging Drug? (David Sinclair Book LIFESPAN – Part 4)


So this is part 4 in the series on
LIFESPAN, the new book by David Sinclair. I’m having a blast on it because he
covers articles… he covers items that I’ve done videos on. This one I’m very
passionate about metformin and anti-aging. This is the TAME study. This is Nir
Barzilai. TAME stands for “Targeting Aging with Metformin.” Dr. Barzilai is the
principal investigator, but as I’ve said many times, there were dozens of
gerontologists (people that study aging) involved in the development of this study.
Now why would we want to use metformin for anti-aging? What
they’re looking for is a composite outcome things, like decrease eye disease,
decreased kidney disease, decreased cancer, decreased heart disease, decreased
stroke, decrease cognitive decline. So hopefully that begins to make the
point why metformin is the most widely prescribed anti-diabetic medication in the world. And it decreases hepatic gluconeogenesis. However, as David Sinclair would say, it
also up right-up regulates or amps up AMPK. Now, why is AMPK an issue? And why is
David Sinclair focusing on it? Well, this is an overview of all of the places in
the metabolism where metformin impacts different places that drive aging, like
TNF (Tumor Necrosis Factor alpha), IGF (insulin-like growth factor),
insulin and it’s a receptor AMPK. David Sinclair mentions in his book mTOR
as I think is mentioned in the book and we’ve mentioned multiple other places as
well. These are all SIRT1. David Sinclair discovered the SIRT enzymes
which again are very involved in driving the epigenetics and the metabolism
associated with insulin resistance and broader aging components. So this is just
another quick look from a recent article in the New England Journal. It
mentions AMPK and insulin resistance, insulin and insulin-like growth
factor. This article you may recognize is on autophagy. So again,
hopefully helping connect quite a few dots here. Again, why metformin? As I’ve
said before, it’s been used safely for over 60 years. It’s associated with
decreased cancer, decreased cognitive decline, and all those other diseases that
we mentioned. How did they develop a composite outcome? Again, they wanted
things that were age-related, common in populations, and created a
significant health risk. Again, I’m not going to repeat the different items that
were included. When you look at 3 of the key diseases that we’re talking
about (and I’ve already mentioned them), they are already associated with
decreased problems when you’re taking metformin. Here’s an example.
Observational studies metformin and cardiovascular outcomes. We saw that in
the MACE study the VA/Medicare… I’m sorry… the VA/Medicare database, Canadian study,
REACH study. the VA patients study cancer. As you see on this, I think this is
called Christmas tree plot. Multiple studies out there showing that
people that were on metformin were on this left side of this vertical line.
What does that mean? That means they were less likely to get cancer.
How about cognitive decline? Again, multiple studies with the Singapore
Longitudinal Aging Study, Cheng with the Taiwan database, Hsu with health
insurance in Taiwan, several others. Again, decreased dementia associated with use
of metformin all cause mortality. In other words, remember I talked about
we’ve talked about this before in other studies, something may have a huge
positive impact on cardiovascular disease ver since. Even though heart
attacks and strokes are only… they are the number one… and what number three
cause of death? They still only cause about a third of deaths overall, so you’d
have to have a huge impact for something that decreases heart attack and
stroke and also decreases total mortality. That’s exactly what you
see with metformin. Again, underlining the strength of the association with
anti-aging and positive impacts using this medication, there’s other components.
I’ve already mentioned these before. This is repetitive. The TAME study design.
They’re looking at 850 milligrams two times a day, and it’s a double-blind
randomized placebo-controlled trial. So you can’t get any better in terms of the
type of study. Now, what’s the inclusion criteria? Unfortunately, they’re looking
at people 65 to 79. I think they’re waiting too late. David Sinclair, for
example, started taking metformin in his late 40s. I started taking it in my
mid-50s, late fifties. Where’s the TAME study now? Well, this is like the third or
fourth video overall out of over 600. So don’t that I’ve done on time. So again
I’ve done three or four. If you don’t remember them, don’t worry about it, we’ve
covered most of the materials here. Here’s the problem. I don’t think it’s
completely fun to do. This is a Forbes article on the TAME study from February
of this year. In our first videos two years ago, we talked about how it
couldn’t be. It wasn’t being funded yet and how the
NIH was fighting it. Because it’s against aging. And they can’t find something
that’s against aging. They can only fund countermeasures against disease. So kind
of weird. But Barzilai was fighting the good fight now about a year ago. We
heard that it got funded. Haven’t heard the results though, and this may be
why. If you look at the rest of this Forbes article from February and AMFAR (the
American Federation for Aging Research) has committed 35 million
dollars to it. They’re hoping for another 40 million from NIH.
However, NIH is still dragging its feet. Because it’s not a disease. It’s
anti-aging. Obviously, you know, the obvious question comes up, “Why don’t they
just label it as one of these diseases?” I’m not there.
I’m not involved in that battle. Anyhow, one other thing that we can say is that
the Big Pharma are not involved in funding this heck. Why would they? Who’s
gonna make any money off that form? It doesn’t make sense to them. But it does
make sense to me, and it’s unfortunate that so few people have
investigated this more deeply. This was a long video. I appreciate your interest,
especially if you’ve made it this far. So I’m very excited to announce we now have
a membership page. Now, what is that? That’s the one place where you can go
and access all of our digital products. It starts off with a few free things,
like a lot of infographics which help you understand the basics of insulin
resistance, cardiovascular inflammation, and other key concepts on how to prevent
heart attack and stroke. The next free item is the intro and first chapter of
the book that we’re writing on plaque and the standards of medicine just
aren’t doing very well right now in terms of the number one killer and
disabler – plaque. We don’t do a good job of measuring it, we don’t do a good job
of monitoring it, and there are better ways. So that’s what this book is all
about. Again, go in, get a free a look at the intro and in the first chapter. And
if you’ve purchased the cardiovascular inflammation and IR courses, thank you so
much for doing that. You purchased those at a time before we had them totally
cleaned up. And we’ve cleaned them up now, and they’re available for you right
there on the membership page. Hit the link below, register and go in, and take a
look. Look forward to seeing you there. Thank you.

34 thoughts on “Metformin: Anti Aging Drug? (David Sinclair Book LIFESPAN – Part 4)

  1. Thanks for the VDO again!! Dr. Brewer, would you recommend Metformin for someone over 60 years, but is for certain not IR, ie.not (Pre)-diabetes?

  2. I'm keto, in my 40s and not diabetic. My mom was visiting so I tried her 500mg Metformin mid day. It made me so sleepy I had to take a nap. I never took it after that. Maybe I should reconsider but take it before bedtime for anti aging.

  3. For anti aging, I suggest you also read The Kaufmann Protocol by Dr. Sandra Kaufmann. She also recommends Metformin. Many YouTube videos show her presenting her protocol. I especially like the one she gave at a People unlimited meeting.

  4. Thank you Dr. Brewer. My opinion….NIH, Natl Inst. of HEALTH…they should fund the study, since the H stands for HEALTH. Excellent video!

  5. Dr. Brewer, thanks for the videos they've been very informative. I'd like to get your opinion on something else if you don't mind. I recently got a liver function panel and all tests were in the normal range except for alkaline phosphatase which was low at 37. My doctor was not concerned but I wanted to know if you think I should look into it further. Thanks in advance.

  6. The only problem we have with medications that do great things it is constantly bombarded by any amount of negativity the anti drug Community can throw at it. People tend to look at big Pharma being the evil empire when they should start looking at the anti drug Community as an evil opposition. What people need to understand is in 1900 the life expectancy was 48 years old. It is now 76.6 years old so what I'm saying is we are not living longer because of some of us evolving into superhumans the medicine and doctors are much better along with technology that is what's keeping us alive longer so big Pharma can't be all that bad

  7. I’m on berberine but not metformin because I read that there were clinical studies that showed the supplement berberine outperformed metformin. There was no referral as to which study and where so I was wondering if you knew anything about this.

    Thanks so much for all this and I too am enjoying Dr. Sinclair book, even though it’s a tough read for those of us without a degree in organic chemistry. But what really has helped is discovering a GLOSSARY in the back of the book.

  8. None of the doctors where I live would ever prescribe metformin for me. All of them blindly follow guidelines written by special interests.

  9. It makes me feel sick and week. Metformin as a cause of late-onset chronic diarrhea. … Gastrointestinal adverse effects such as abdominal pain, nausea, dyspepsia, anorexia, and diarrhea are common and widely accepted when occurring at the start of metformin therapy. Diarrhea occurring long after the dosage titration period is much less well recognized.

  10. It would be great if the researchers could find organizations with aligned interests (to healthy aging). For example a big health insurance company.

  11. If metformin can deplete vitamin B12, how often should one get their B12 level checked?

    Also, people often say metformin helps with weight loss. If one is trying to gain weight rather than lose weight, would metformin make gaining weight more difficult?

  12. I took metformin for many years (20 years) for polycystic ovaries
    and I still had to remove my endometrium and ovaries. So, not sure it reduces
    anything to be honest. 🙂 Plus after taking it for 3 years I got severe RA. Not
    sure it is related. However, no one knows what causes it. The funny thing is
    some people say : That medication have not cause it! My answer is: how do you
    know that it did not cause it if you don't know what cause it?. But hey, pharmaceutical
    are always trying to find ways to increase the selling of a drug. RA cure is
    the Holy grail right? It can be mercury, cavitation, teeth infections and vaccinations.
    I loved Metformin as I lost 8 kilos when I start taking it but it was probably
    diet and I couldn't stop taking it because I was afraid to put on weight. Not a
    good thing to be afraid. Now I am off it, thanks God and on a vegan gluten free
    diet. I own my life to RA medication but every day I ask God to be off it.
    Relationship between RA and metformin aside from having RA and Hypothyroidism (1
    year later) after taking Metformin? By the wayI was taking 750 twice a day!

  13. I asked my doctor for Metformin. I had been prescribed Fortamet in the past but I kept hearing scary things about it like lactic acidosis and quit taking it. Now I think that was Satan talking. Anyway, I was sent away with no Metformin.

  14. Dr. Brewer…. I would be interested in deep diving down to see if the drug ACTUALLY does something other than lower the insulin and effect glucose. IE, many test results on other drug factors have shown the diet fed to the contributors was a typical or WORSE SAD. How would a Keto/LCHF/PSMF WOE individual fare with metformin? Could one substitute Berberine instead of Metformin ?

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